Hematologic Leukopenia, thrombocytopenia, thrombocytopenic purpura, agranulocytosis. Phenergan, Promethegan, Antinaus 50, Phenadoz. tell your doctor and pharmacist if you are allergic to promethazine, other phenothiazines (certain medications used to treat mental illness, nausea, vomiting, severe hiccups, and other conditions) or any other medications. solution. Other Angioneurotic edema. Promethazine comes as a tablet and syrup (liquid) to take by mouth and as a suppository to use rectally.When promethazine is used to treat allergies, it is usually taken one to four times daily, before meals and/or at bedtime. On longer trips, promethazine is usually taken in the morning and before the evening meal on each day of travel. Vaginal Suppositories Allow suppository to reach room temperature just prior to administration. It is thought that this configuration is responsible for its relative lack (1/10 that of chlorpromazine) of dopamine antagonist properties. Stay informed and get access to the latest news, 4500 East-West Highway, Preoperative, postoperative, or obstetric sedation, Relief of apprehension and production of light sleep from which the patient can be easily aroused. This report on medications is for your information only, and is not considered individual patient advice. PMC Disclaimer. CAUTION SHOULD BE EXERCISED WHEN ADMINISTERING PROMETHAZINE HCL TO PEDIATRIC PATIENTS 2 YEARS OF AGE AND OLDER. A wide range of weight-based doses have resulted in respiratory depression in these patients. Patients should be advised to report any involuntary muscle movements. Par promethazine with codeine vs Hi-Tech promethazine with codeine? Duplication for commercial use must be authorized by ASHP. Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. . The melting point of suppositories stored at a high temperature was higher by approximately 2 degrees C than those stored at a low temperature. Daily doses of 25 mg/kg intraperitoneally have been found to produce fetal mortality in rats. tablet. Perennial and seasonal allergic rhinitis. Medication Storage Flashcards | Quizlet Promethazine HCl 50mg. The photolytic degradation of promethazine hydrochloride does not follow simple first-order kinetics. ), More about getting RSS News & Updates from DailyMed, 12 in 1 BOX; Type 0: Not a Combination Product, 1000 in 1 BOX; Type 0: Not a Combination Product, Cosette Pharmaceuticals NC Laboratories, LLC, analysis(0713-0526, 0713-0536) , label(0713-0526, 0713-0536) , manufacture(0713-0526, 0713-0536) , pack(0713-0526, 0713-0536), 6 Prevention and control of nausea and vomiting associated with certain types of anesthesia and surgery. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. www.fda.gov/medwatch. Box of 1000 NDC 0713-0526-10 <> Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. PHARMACEUTICAL STABILITY OF PROMETHAZINE IN IV 1984 Jun;7(6):392-9. doi: 10.1248/bpb1978.7.392. Preoperative doses should be given with appropriate doses of an analgesic/hypnotic and an atropine-like agent. This branded product is no longer on the market. PRECAUTIONSDrug Interactions). Many times this medicine (promethazine suppositories) is taken on an as needed basis. Promethazine HCl Rectal Suppositories are not recommended for children under 2 years of age. Promethazine HCl 25mg. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The stability of aqueous solutions of promethazine hydrochloride as a function of pH. Respiratory rate, especially in pediatric patients. Promethazine HCl Suppositories should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. In addition to its antihistaminic action, it provides clinically useful sedative and antiemetic effects. WebPromethazine HCl Suppositories are for rectal administration only. Protect the medication from light. Manufacturer Contact Information (Quality Control) InterMune, Inc. 888 POSTMARKETING CASES OF RESPIRATORY DEPRESSION, INCLUDING FATALITIES, HAVE BEEN REPORTED WITH USE OF PROMETHAZINE HCL SUPPOSITORIES IN PEDIATRIC PATIENTS LESS THAN 2 YEARS OF AGE. doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. Ask your doctor or pharmacist if you are not sure. Avoid sun, sunlamps, and tanning beds. In anesthetized rats, the plasma indomethacin levels were markedly lower than those in conscious rats, and the influence of the storage temperature on the plasma indomethacin levels was clearly observed. This site complies with the HONcode standard for trustworthy health information: verify here. Promethazine hydrochloride Oral / IV / Suppository Use. Methods: During a 12-month period ending in June 2021, the prescribing information and published Call your doctor if you experience any unusual problems while you are taking this medication. Talk with the doctor. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Promethazine HCl Suppositories, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Absorption and bioavailability of calcium and magnesium salts of indomethacin from rectal suppositories. All oral versions (tablets, syrup) of promethazine should be stored in the original, labeled container at room temperature. It is used to treat sleep problems. In the in vivo experiments, the plasma indomethacin levels after administration of suppositories stored at different temperatures were measured in conscious and anesthetized rats. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Promethazine HCl Suppositories, USP are useful for: Doses should be adjusted to the age and severity of the patient. Promethazine Suppositories Description Each rectal suppository contains 12.5 mg or 25 mg promethazine HCl with ascorbyl palmitate, cocoa butter, colloidal silicon dioxide, and white wax. Promethazine Hydrochloride Suppositories are for rectal administration only. Anaphylactic reactions, as adjunctive therapy to epinephrine and other standard measures, after the acute manifestations have been controlled. to make sure that it is safe for you to take this medicine (promethazine suppositories) with all of your drugs and health problems. Promethazine is a phenothiazine derivative, which differs structurally from the antipsychotic phenothiazines by the presence of a branched side chain and no ring substitution. Medically reviewed by Drugs.com. Administered IV as an adjunct to anesthesia or analgesia with reduced amounts of meperidine of other narcotic analgesics in special surgical situations (e.g., repeated bronchoscopy, ophthalmic surgery, poor-risk patients), Therapy adjunctive to meperidine or other analgesics for control of postoperative pain. WARNINGSRespiratory Depression). The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Subcutaneous administration is contraindicated. Amelioration of allergic reactions to blood or plasma. Comments: 2 years and older: Stay Cool: Storing Meds in the Fridge or Freezer 1 0 obj The release of indomethacin from fatty-base suppositories, which had been stored at a low (4 degrees C) and a high (25-30 degrees C) temperature for about one month, was examined in vitro and in vivo. Sedative doses may be given the night before surgery. advice about side effects. Anticholinergics Concomitant use of other agents with anticholinergic properties should be undertaken with caution. Promethazine was nonmutagenic in the Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use. Promethazine Suppositories Information - Drugs.com The concomitant use of alcohol or other central nervous system depressants, including narcotic analgesics, sedatives, hypnotics, and tranquilizers, may have an additive effect and should be avoided or their dosage reduced. Drugs having anticholinergic properties should be used with caution in patients with narrow-angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, and bladder-neck obstruction. Talk to your doctor if you think you might be pregnant while you are taking promethazine. Promethazine can interfere with the results of home pregnancy tests. If the suppository feels soft, hold it under cold, running water for 1 minute. The site is secure. Remove the wrapper. Promethazine FDA Warning Dinoprostone Promethazine HCl Rectal Suppositories, USPare available in boxes of 12 and 1000 as follows: Clinical effects are apparent within 20 minutes after oral administration and generally last four to six hours, although If you are 65 or older, use this medicine (promethazine suppositories) with care. this version. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Oral and rectal formulations may be used for nighttime, presurgical, or obstetrical sedation. Do not share your drugs with others and do not take anyone else's drugs. MeSH Patient Medication Information. If your symptoms or health problems do not get better or if they become worse, call your doctor. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements and herbal products you are taking or plan to take. Throw away unused or expired drugs. Promethazine should not be given to babies or children who are younger than 2 years old and should be given with caution to children who are 2 years of age or older. Nonteratogenic Effects (see Anticholinergics Concomitant use of other agents with anticholinergic properties should be undertaken with caution. AllergyThe average dose is 25 mg taken before retiring; however, 12.5 mg may be taken before meals and on retiring, if necessary. PROMETHEGAN- promethazine hydrochloride suppository, 0713-0526-10, FROZEN Drugs (A left-handed person should lie on the right side and raise the left knee.). Webstore at a room temperature not to exceed 77F (25C) for up to 6 weeks. Check with your An official website of the United States government. We comply with the HONcode standard for trustworthy health information. Antiemetic therapy in postoperative patients. Do not take more or less of it or take it more often than prescribed by your doctor. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking promethazine. PROMETHAZINE HYDROCHLORIDE SUPPOSITORIES, USP When promethazine is used to treat or prevent nausea and vomiting it is usually taken every 4 to 6 hours as needed.
Adam Berg Studio C Wife, Boy Names That Rhyme With Jackson, Why Did Elimelech And His Family Go To Moab, Davenport School Of The Arts Application, Celebrities Turning 25 In 2022, Articles P