One study, published in Phytotherapy Research, reported that ashwagandha supplementation reduced blood sugar and A1c levels, although this was a relatively small study. These are drugs like diazepam, lorazepam, phenobarbital, or zolpidem. Ashwagandha, also known as 'Indian Ginseng' is an evergreen shrub indigenous to India, the Middle East, and some parts of Africa. It is also recommended that people with hormone-sensitive prostate cancer avoid using ashwagandha due to possible hormone changes caused by the herb. With such a long list of claims, it's important to look closely at the research. doi:10.7759/cureus.6466, Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: a randomized, double-blind, placebo-controlled study. Ashwagandha can react with certain medications and supplements you may already take, and result in adverse effects. https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms. Phytother.Res 2010;24(1):129-135. View abstract. Yes: Ashwagandha is a wonderful tonic that reduces inflammation, balances hormones and supports immune function. Jahanbakhsh SP, Manteghi AA, Emami SA, Mahyari S, et al. Drug-induced hepatocellular injury due to herbal supplement ashwagandha. Some barbiturates include phenobarbital, pentobarbital and secobarbital. Thyroid Suppression Test. Guerrero FA, Medina GM. Venkataraghavan S, Seshadri C, Sundaresan TP, and et al. J Ethnopharmacol. People who are pregnant or breastfeeding should avoid using the herb, as not enough is known about its safety. Indian J Exp Biol 1997;35:236-9. In this investigation, participants took either a placebo or 240 milligrams per day of ashwagandha extract. For more information on drug interactions, visit the RxList Drug Interaction Checker. Serotonin syndrome can even result in death. It's much more likely for certain foods, like grapefruit juice or herbal supplements, to affect antidepressant function. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. Ashwagandha might increase the sedative effects of benzodiazepines, prescribed for conditions such as panic disorder and anxiety, and of barbiturates, primarily used for epilepsy. 1996;35(1):95-100. As this is a relatively new area of research, more vigorous studies are needed. 2012;10(1):48-49. Malhotra, C. L., Mehta, V. L., Prasad, K., and Das, P. K. Studies on Withania ashwagandha, Kaul. Does Ashwagandha Interact With Any Medications? 1965;9(3):127-136. This information may not fit your specific health circumstances. You may think that these supplements are safe because they also have antidepressant effects, but it's not that simple. Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency. Archana R, Namasivayam A. Antistressor effect of Withania somnifera. An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). Additionally, ashwagandha may increase testosterone levels in the body. Because ashwagandha supports immune system function, it might interact with medications designed to reduce immune system activity, known as immunosuppressants, according to the University of Maryland Medical Center. If you're interested in taking a nutritional supplement to support your treatment for depression, talk to your doctor so you can find the one that works best for you and doesn't affect your antidepressants. Evid Based Complement Alternat Med. View abstract. Bhattacharya SK, Satyan KS, Ghosal S. Antioxidant activity of glycowithanolides from Withania somnifera. Synthroid is not known to interact with these supplements. The Incredible Benefits of Ashwagandha Leaves for Weight Loss In general, Ashwagandha is thought to be safe when used in moderate amounts. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. 2008;6:14. Ashwagandha and other dietary supplements should never replace standard medicine or care. 2020;40(4):825-829. doi:10.1111/liv.14393, Siddiqui S, Ahmed N, Goswami M, Chakrabarty A, Chowdhury G. DNA damage by withanone as a potential cause of liver toxicity observed for herbal products ofWithania somnifera(ashwagandha). View abstract. However, many studies supporting the use of ashwagandha are small or poorly designed. A recent study looked at the health claims and safety of ashwagandha and found that the herb has shown anticancer, anti-inflammatory, heart-protective, liver-protective, and immunomodulatory (able to change the immune system) actions. metoprolol, nebivolol, propranolol), Diuretics (e.g. This can result in serotonin syndrome, which causes side effects like anxiety, sweating, confusion, tremors, lack of coordination and an accelerated heart rate. View abstract. Some don't work well with prescription medicines. Select a condition to view a list of vitamins. However, scientific evidence supporting these and other uses is poor. Gopal S, Ajgaonkar A, Kanchi P, et al. J Med Food 2022. Ashwagandha's leaves contain a compound that causes sleep induction and is used for treating insomnia. Ashwagandha is an evergreen shrub that grows in Asia and Africa. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. Indian J Med Res 2015 Jan;141(1):100-6. Immunopharmacol.Immunotoxicol. However, SSRIs don't work for everyone, and other antidepressants work via different pathways in your body. Animal research and one case study indicate that the herb might increase serum concentration of thyroid hormones, according to Ray Sahelian, a medical doctor who specializes in natural supplements. It's worth noting that a drawback of both these studies is that they were performed on small sample sizes. Aerobic capacity and recovery were assessed for all participants throughout the study. The Best Brain Supplements For Cognitive Health - Forbes Gupta, S. K., Dua, A., and Vohra, B. P. Withania somnifera (Ashwagandha) attenuates antioxidant defense in aged spinal cord and inhibits copper induced lipid peroxidation and protein oxidative modifications. Devi, P. U., Sharada, A. C., Solomon, F. E., and Kamath, M. S. In vivo growth inhibitory effect of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma 180. Ashwagandha (Withania somnifera) is a natural herb used for centuries in Ayurveda. 2012;34(3):255-62. As with many other herbal supplements, little research is available on possible interactions. Phytother Res 2022. Chengappa KN, Bowie CR, Schlicht PJ, Fleet D, Brar JS, Jindal R. Randomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorder. Curr Clin Pharmacol. Examples of immunosuppressants include azathioprine, cyclosporine, mycophenolate, prednisone and corticosteroids. Phytotherapy Research 1989;3(5):201-206. Assessment of Withania somnifera root extract efficacy in patients with generalized anxiety disorder: A randomized double-blind placebo-controlled trial. Study participants were randomized to receive a placebo, 225 milligrams per day of ashwagandha, or 400 milligrams per day of ashwagandha for 30 days. A few commonly prescribed benzodiazepines are: Alprazolam (Xanax) Clonazepam (Klonopin) Diazepam (Valium) Lorazepam (Ativan) Liver Int. View abstract. Does Ashwagandha interact with other medications? Find - Forest Raga Ashwagandha And Lexapro (An Overview) | OptimistMinds PLoS One. Indian J Exp Biol. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. Ashwagandha may interact with various medications. Levothyroxine (Synthroid) Supplement Interactions -- Supplements To 1981;19(3):245-249. Davis, L. and Kuttan, G. Effect of Withania somnifera on DMBA induced carcinogenesis. The exact type of antidepressant you're taking will determine which foods, vitamins and supplements you should or should not ingest. How to use To use ashwagandha products safely, people must always follow the dosage advice given by the manufacturer. Still, a seal of approval from one of these agencies is your best bet for supplement quality since dietary supplements and herbs are not regulated in the United States. Be sure to confirm new supplements fit your dietary needs or preferences. This includes: As with many other herbs and supplements, ashwagandha has a risk of side effects. Who Shouldn't Take Ashwagandha? 2020;12(4):1119. Ashwagandha's cortisol-lowering effects may be responsible. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. 2021 Feb 11;6(1):20. doi: 10.3390/jfmk6010020. Brain Behav. Ashwagandha. J Ethnopharmacol. View abstract. Take ashwagandha with these drugs only under your doctor's supervision, recommends the Langone Medical Center at New York University. Health Sci Rep 2022;5(4):e741. Monitor your blood pressure closely. The herb has been proven to interact with many other drugs, the interaction with SSRI (selective serotonin reuptake inhibitor) or Benzodiazepines are not proven scientifically. Is Fish Oil Dangerous With Antidepressants? Ashwagandha is not naturally found in foods, which means the only way to get it is through supplements. View abstract. 2013;74(11):1076-83. According to the Cleveland Clinic, there are six different types of medications commonly used to treat depression. View abstract. Dhuley, J. N. Effect of ashwagandha on lipid peroxidation in stress-induced animals. After 30 days, those who took either dose of ashwagandha self-reported positive effects on their anxiety. Cureus. Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. Taking high doses of ashwagandha may increase your risk of side effects. Phytotherapy Research 1991;5:111-114. The April 2008 issue of "Therapeutic Drug Monitoring" notes that some herbal products interfere with methodology used to measure drug levels in a patient's bloodstream. There aren't any specific antidiabetic drugs ashwagandha is known to interact with. Cureus. Phytomedicine 2000;7(6):463-469. 8 Warning Signs of Depression You Shouldn't Ignore, Depression in Adults With a Chronic Physical Health Problem: Treatment and Management, How Vegans Can Get All Their Nutrients (Without Taking Supplements), Complementary Therapies in Medicine Journal, 15 Celebrities Who Struggle With Anxiety and Depression, Australian Journal of Herbal Medicine: "B Vitamins Enhance Antidepressant Response in Adults", Open Neurology Journal: "Vitamin B12 Supplementation in Treating Major Depressive Disorder: A Randomized Controlled Trial", Journal of Psychiatry: "Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses", Mayo Clinic: "MAOIs and Diet: Is It Necessary to Restrict Tyramine? View abstract. Ashwagandha: ADHD Uses, Warnings, Side Effects, Dosage - MedicineNet Chronic stress increases cortisol levels, leading to lower levels of T3 and T4. Medically reviewed by Drugs.com. Chitre D, Nadkarni S, Jagtap N, et al. It may also interact with other herbs, supplements, and even foods. View abstract. Byetta, Trulicity, Ozempic, Rybelsus, Bydureron, Victoza, Mounjaro), Sulfonylureas (e.g. Cooley K, Szczurko O, Perri D, et al. Significant improvements were seen in all sleep parameters for those who took ashwagandha (300 milligrams twice daily). 2019;98(37):e17186. View abstract. Created for people with ongoing healthcare needs but benefits everyone. Ashwagandha has mild interactions with at least 29 different drugs. doi:10.1097/MD.0000000000017186, Pratte MA, Nanavati KB, Young V, Morley CP. Herbal supplements can strongly affect the body. View abstract. When people can't obtain all of the nutrients the Food and Drug Administration recommends, they typically look into taking supplements. Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider's examination and assessment of a patients specific and unique circumstances. Moreover, researchers also noted several limitations of the studies included, such as the varying methods used to assess sleep quantity and quality. Some evidence suggests that ashwagandha may interact with: Before starting a new supplement, it is vital that you carefully read the ingredients list and nutrition facts panel to know which ingredients and how much of each ingredient is included in the supplement. Dhuley, J. N. Therapeutic efficacy of Ashwagandha against experimental aspergillosis in mice. Ashwagandha has not been well studied in regard to potential interactions with prescription medication. The ashwagandha root extract has been used for thousands of years as an herbal remedy in Ayurveda, the ancient Indian medical system. What Happens If I Take Too Much Ashwagandha? Safety studies have not been performed on these populations, so it's best to avoid using ashwagandha altogether while pregnant or breastfeeding. and treatment options, including any risks or benefits regarding use of medications. More are needed for more definitive results. 2016;5(4):40. doi:10.3390/antiox5040040, Vitale KC, Hueglin S, Broad E. Tart cherry juice in athletes: a literature review and commentary. 2021 Nov 25;13(2):100510. Ashwagandha is native to India and Southeast Asia and is one of the most important herbs in Ayurveda, an alternative natural system of medicine that originated in Indian over 3,000 years ago. The best time to take ashwagandha is at the time that works best for you. Diarrhea. Does Ashwagandha Interact With Any Medications? You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Change in balance, feeling shaky, or unsteady, Not able to think clearly or change in thinking, US Department of Defense Dietary Supplement Resource, https://www.opss.org/article/ashwagandha-dietary-supplement-products, This generalized information is a limited summary of diagnosis, treatment, and/or medication information. . When multiple foods or supplements are processed by your body via the same exact route, they may compete with one another. Integr Cancer Ther. Nagashayana N, Sankarankutty P, Nampoothiri MRV, et al. Taking ashwagandha along with sedative medications might cause too much sleepiness. National Institutes of Health Office of Dietary Supplements. For more information, read the "What else do I need to know?" section below. Due to an overall lack of scientific evidence, there are no standard dosage guidelines for ashwagandha. First and foremost, I want to point out this it can tricky to determine whether or not a dietary/herbal supplement will interact with prescription drugs due to a general lack of studies on the matter. Taking ashwagandha with thyroid hormone pills might cause too much thyroid hormone in the body, and increase the effects and side effects of thyroid hormone. ; Vomiting and nausea. Read more: 15 Celebrities Who Struggle With Anxiety and Depression. Biogerontology. For most people, ashwagandha is a safe and effective supplement for taking the edge off stress. Nutrients. ashwagandha - medtigo The plan to ashwagandha blood pressure medication interaction enter the company was does blood pressure medication make you put on weight quietly implemented the one from Hebei do hypertension medications affect sexuality University has already started the procedure the Yinchuan University s Zhou Qitian also agreed, and the next step is to do the school work Inner Mongolia can probiotics lower . 2020;72:28-36. Pharmacological evaluation of ashwagandha highlighting its healthcare claims, safety, and toxicity aspects. It is essential to talk to your healthcare provider before taking ashwagandha if you are taking any other substances. Anyone with upcoming surgery should stop using ashwagandha at least two weeks prior. 2011;68(1):3-8. Bull Natl Res Cent. Some research shows that ashwagandha may provide benefits for stress, anxiety, memory loss, insomnia, and other health conditions. Kumar S, Bouic PJ, Rosenkranz B. Chauhan S, Srivastava MK, Pathak AK. Hydroxyzine has moderate interactions with at least 207 different drugs. Some herbal supplements with antidepressant properties are safe to consume alongside medications. Dosage: How Much Ashwagandha Should I Take? Therefore, before using this product, tell your doctor or pharmacist of all the . At the end of the study, significant improvements in general memory and immediate memory were seen in the ashwagandha group. Naturopathic care for anxiety: a randomized controlled trial ISRC TN78958974. The average vitamin or mineral should not affect your antidepressant's functionality or your health. Bhattacharya, S. K., Bhattacharya, A., Sairam, K., and Ghosal, S. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. Cureus 2022;14(10):e30433. View abstract. If you take thyroid medicine, consult your doctor before using ashwagandha. Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. No, that's not true all the time. Researchers from another review concluded that ashwagandha might be useful in conditions such as: Studies used in this review included human, animal, and lab research. A total of 525 drugs are known to interact with Xanax. This product may interfere with some lab tests. By Mayo Clinic Staff Herbal supplements are natural, so they must be safe, right? Bonilla DA, Moreno Y, Gho C, Petro JL, Odriozola-Martnez A, Kreider RB. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Kamal HI, Patel K, Brdak A, Heffernan J, Ahmad N. Ashwagandha as a unique cause of thyrotoxicosis presenting with supraventricular tachycardia. Ashwagandha, an herbal supplement commonly used in traditional Indian medicine, is the latest fad herb trending on social media. Devi, P. U., Sharada, A. C., and Solomon, F. E. Antitumor and radiosensitizing effects of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma-180. I recommend taking it at bedtime for a better night's rest or you can take it during the day. Cheah KL, Norhayati MN, Husniati Yaacob L, Abdul Rahman R. Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis. The comparative effect of milk fortified with Aswagandha, Aswagandha and Punarnava in children - a double-blind study. Therefore,it could theoretically increase the risk of hypoglycemia (i.e. View abstract. Speak with a, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Mediterranean, Low-Fat Diets Are Best for Heart Problems, Least Amount of Exercise You Need to Stay Healthy, Nerve 'Pulse' Therapy May Help Ease Sciatica, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Attention deficit-hyperactivity disorder (ADHD), Chronic obstructive pulmonary disease (COPD), Antipsychotic-induced metabolic side effects, Think Your Child Has ADHD? Ashwagandha - Diazepam Interaction Details | HelloPharmacist Some of the more compelling potential uses of ashwagandha are outlined below. Can Ashwagandha and SSRI be taken together? - iCliniq This is called a medicine interaction. In the study, participants received either a placebo or 600 milligrams per day of ashwagandha for eight weeks. Association of l-DOPA with recovery following Ayurveda medication in Parkinson's Disease. Ashwagandha is purported as useful for relieving stress, fatigue, pain and gastrointestinal problems, and treating diabetes, rheumatoid arthritis and epilepsy. Does Synthroid interact with supplements that may help with arthritis, such as ashwagandha, collagen, or turmeric? Curr Sports Med Rep. 2017;16(4):230-239. doi:10.1249/JSR.0000000000000385. 13 Supplement or Medication Combos You Should Never Mix National Center for Complementary and Integrative Health. Jardiance,Farxiga, Invokana), ACE-Inhibitors (e.g. Can I Take Lexapro & Vitamin Supplements? Supplements That Are Similar to Ashwagandha. Withania somnifera, known as ashwagandha, has a role in ayurvedic medicine for a wide range of health conditions. A recent study out of India compared varying doses of ashwagandha to a placebo for the treatment of stress. 8-16-1995;95(1-2):189-193. A total of 203 drugs are known to interact with levothyroxine . 2021;272:113929. doi:10.1016/j.jep.2021.113929, Bonilla DA, Moreno Y, Gho C, Petro JL, Odriozola-Martnez A, Kreider RB. People taking certain medications may need to avoid using ashwagandha. Effects of ashwagandha (Withania somnifera) on physical performance: systematic review and Bayesian meta-analysis. View abstract. Ashwagandha has been traditionally used for anxiety, insomnia, aging, and other conditions that may be exacerbated by stress. Liver damage. However, certain vitamins, supplements and medications are processed via the same enzymatic pathway (cytochrome P450) as your antidepressants. J Evid Based Complementary Altern Med. In 2020 and 2021, some people began using ashwagandha to diminish the harmful effects of COVID-19, although there is no evidence to support that use. Am J Ther 2023;30(1):e80-e83. Evid Based Complement Alternat Med. You can mix other nonessential amino acids and antidepressants without any issues. View abstract. Last updated Apr 30, 2023 Key points Ashwagandha has not been well studied in regard to potential interactions with prescription medication. View abstract. 2022;15(9):1067-1080. doi:10.1080/17512433.2022.2121699, Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of Ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. J.Altern.Complement Med. Will Ashwagandha Interact With Diabetic Meds Drugs that cause sleepiness and drowsiness are called sedatives. Ashwagandha: Benefits, Side Effects, Dosage, and Interactions J Ethnopharmacol. Overall, ashwagandha doesn't seem to have many reported significant drug interactions. Curr Res Toxicol. Be aware that antidepressants and vitamins typically work with each other the vitamins won't replace your medication. Ashwagandha - An Herbal TikTok Sensation | Science-Based Medicine Its effect on arterial blood pressure in anaesthetized dogs. Consult a doctor before taking any medication. Dasgupta A, Peterson A, Wells A, Actor JK. lisinopril, captopril, benazepril, quinapril), ARBs (e.g. There are a variety of essential vitamins and minerals you should consume on a daily basis. Serotonin syndrome can even result in death. View abstract. 2020. ashwaganda: Dosing, contraindications, side effects, and pill pictures - epocrates online Drug Lookup: Browse: Drugs Alt Meds Select a medication above to begin. Katz M, Levine AA, Kol-Degani H, Kav-Venaki L. A compound herbal preparation (CHP) in the treatment of children with ADHD: a randomized controlled trial. Safety of ashwagandha root extract: a randomized, placebo-controlled, study in healthy volunteers. Ashwagandha may help the body cope with stress. A November 2013 study in the Open Neurology Journal found that vitamin B12 could also help reduce symptoms of depression, while a March 2015 study in the Australian Journal of Herbal Medicine found that several B-complex vitamins could help reduce depressive symptoms. Am J Drug Alcohol Abuse 2009;35(1):1-11. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. This information does not contain all possible interactions or adverse effects. Thank you, {{form.email}}, for signing up. Some of these interactions can be life-threatening. View abstract. Most ashwagandha supplements are naturally vegan and gluten-free. Ashwagandha can also interact with some medications and affect how they work. ", Mayo Clinic: "Selective Serotonin Reuptake Inhibitors (SSRIs)", Cleveland Clinic: "Depression Medicines: Risks / Benefits", Shanghai Archives of Psychiatry: "Use of Antipsychotics in the Treatment of Depressive Disorders", Food and Drug Administration: "Vitamins and Minerals Chart", World Journal of Biological Chemistry: "Complexity of Vitamin E Metabolism", NCBI Bookshelf: "Depression in Adults With a Chronic Physical Health Problem: Treatment and Management", Journal of Medicine and Life: "Nutrition and Depression at the Forefront of Progress", Harvard Health Publishing: "Cytochrome P450 Enzymes and Psychiatric Drugs", Complementary Therapies in Medicine Journal: "Evaluation of the Efficacy of Withania Somnifera (Ashwagandha) Root Extract in Patients With Obsessive-Compulsive Disorder: A Randomized Double-Blind Placebo-Controlled Trial", Serotonin and norepinephrine reuptake inhibitors (SNRIs), Norepinephrine and dopamine reuptake inhibitors (NDRIs), Noncompetitive N-methyl-D-aspartate receptor antagonists.
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