Calcium Supplements Your doctor can also help you decide if the benefits of Prolia treatment outweigh your risks of side effects. Prolia can cause both mild and serious side effects. But weight gain may be a symptom of a side effect called peripheral edema. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. You may report side effects to FDA at 1-800-FDA-1088. For a basic overview of Prolia, including details about its uses, see this article. 2,4. Prolia can cause peripheral edema (fluid retention) or swelling, and this may lead to weight gain in some people. Some reports may have incomplete information. Certain side effects of Prolia that may last longer than others include: Ask your doctor about serious or long-lasting side effects of Prolia and what you should know before starting this drug. (BMD is a measurement of the amount of minerals such as calcium in your bones.) (With off-label use, a drug is used to treat conditions other than those its been approved to treat.). Prolia contains the active ingredient denosumab. What should I know about Prolia vs. Evenity? See your dentist regularly. Side effects are possible with Prolia use, but in most cases they go away after a while. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. The study uses data from the FDA. Calcium supplements may help support bone and teeth health. Also, hair loss may be related to other medications you take or health conditions you have. With these reports, it wasnt known whether Prolia or something else (such as a different medication) caused the hair loss. (To learn more, see the Side effect specifics section above.). Take only the amount of calcium and vitamin D that your doctor has prescribed. Prolia may cause serious side effects. It is not safe to receive Prolia during pregnancy. for breast cancer that has not spread to other parts of the body. Get emergency medical help if you have signs of an allergic reaction to Prolia: hives, itching, rash; difficult breathing, feeling light-headed; swelling of your face, lips, tongue, or throat. The drug attaches to the RANK protein and helps prevent osteoclasts from breaking down bone. If the user is trying to grow bone due to osteoporosis, osteopenia, or any reason, the recommended intake is 4 capsules divided into 2 doses also taken in the morning and evening with food. What should I know about Prolia vs. Reclast? You Terms of Use. But Prolia is given once every 6 months by a healthcare professional. They include: not getting enough calcium and vitamin D smoking drinking too much alcohol using certain medications, such as corticosteroids and anticonvulsants not getting enough weight-bearing exercise (at least 30 minutes on most days). you can take. Its possible that some of Prolias side effects may be long term, but theyre rare. They can help answer any questions you have about side effects from taking the drug. Can diet help improve depression symptoms? You may need to stop using the medicine for a short time. Learn more about your health after menopause. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. For a detailed breakdown of Prolia versus Xgeva, check out this article. If your Prolia treatment is stopped, talk to your doctor about other medicine that Prolia is meant to be used in combination with calcium and vitamin D supplements. Prolia is a prescription medicine used to treat osteoporosis in men and women who will be taking corticosteroid medicines (such as prednisone) for at least six months and are at high risk for fracture. Below are commonly used dosages, but the dosage you receive will be determined by your doctor. Do not share this medicine with others. Your low blood calcium must be treated before you receive Prolia. But this isnt the case with Prolia. Ask your plan if they cover the drug, and what the cost will be for you. Its recommended that calcium and vitamin D supplements be taken with Prolia. For this reason, some calcium supplements are combined with vitamin D. This vitamin is available in two forms, vitamin D 2 (ergocalciferol) and vitamin Instead, it belongs to a different group of medications called biologics. To prevent osteoporotic fractures, combined calcium and vitamin D supplementation is recommended at the correct dosage (1,0001,200 mg calcium and 800 IU of vitamin D per day). Supplementation should be targeted on vulnerable groups such as elderly and institutionalised people, patients with osteoporosis and individuals on glucocorticoids. Numerous trials have shown that calcium and vitamin D supplementation is effective and safe. In particular, no increased cardiovascular risk was observed. Your doctor should examine your mouth before you start Prolia and may tell you to see your dentist. Prolia WebYour doctor may prescribe calcium and vitamin D to help prevent low calcium levels in Specifically, Prolia is a monoclonal antibody (a lab-made protein). Increased risk of broken bones, including broken bones in the spine, after stopping, skipping or delaying Prolia. But it can increase your risk of serious health problems, such as heart attack. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. Here are a few questions to consider asking your doctor: You can also learn more about osteoporosis treatment options here. They can also tell you about other treatment options available for osteoporosis and bone loss prevention. Talk with your doctor about which other treatments are better choices for you. By stopping RANKL from binding to its receptor Prolia reduces bone breakdown, bone loss, bone pain, and other bone complications. These are serious. This list doesnt include all possible mild side effects of the drug. (To learn more, see the Precautions for Prolia section below.). These treatments may include acetaminophen (Tylenol) or ibuprofen (Advil, Motrin). If your pain is more severe, your doctor may suggest prescription pain medication or physical therapy. Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. If your levels are high, theyll typically recommend lifestyle changes and medication. Prolia They may recommend ways to ease your symptoms and determine whether you should keep taking Prolia. Treating any mouth or dental problems early is the best way to help prevent serious dental complications. Be sure to talk with your doctor about which medication is right for you. Your dentist may have you use a chlorhexidine mouth rinse before and after surgery to reduce your risk for jaw-related side effects. It is often used in osteoporosis. For more information about how Prolia and Zometa compare with each other, see this article. Heres a short list of some of the mild side effects that Prolia can cause. In addition, you should use effective birth control while youre taking Prolia. Prolia and Forteo are both used to treat osteoporosis. WebDrug interactions are reported among people who take Prolia and Calcium. A healthcare provider will give you this injection in a hospital or clinic. If you miss a dose of Prolia, you should receive your injection as soon as you can. If your pain becomes severe, your doctor may recommend other treatment options to replace Prolia. A biologic drug is made from parts of living organisms. Its thought that hair loss could occur due to how Prolia affects your immune system. You may wonder how Prolia compares with the alternative drug Reclast. Mild side effects can occur with Prolia use. Prolia is a prescription medicine used to treat osteoporosis in men and women who will be taking corticosteroid medicines Your risk for infection with Prolia may be higher if you have a weakened immune system. Talk with your doctor about your health history and discuss your risks with Prolia treatment. So, if you want to stop taking Prolia, talk with your doctor. But if they become bothersome, talk with your doctor or pharmacist. And you should continue using birth control for at least 5 months after stopping Prolia. While this drug may be prescribed for children as young as 13 years for selected conditions, precautions do apply. Additionally, in Prolia-treated men with nonmetastatic prostate cancer receiving ADT, a greater incidence of cataracts was observed. You will receive your Prolia injection from your healthcare provider at a their office or clinic. Personalize this study to your gender and age, Arthrotec and Alanine Aminotransferase Increased, Capecitabine and Lumigan drug interaction, Cyramza and Gastrointestinal Stoma Necrosis, Simponi Aria and Pennsaid drug interaction, Docetaxel and Infection In An Immunocompromised Host, Ketorolac Tromethamine and Bladder Obstruction, Roxicodone and Caspofungin Acetate drug interaction, Ginkgo and Nitrofurantoin drug interaction. Although its rare, your doctor may give you the option to self-inject Prolia at home. Motion sickness, nausea, and vomiting can occur as a part of vertigo. And some of these side effects are more common with certain uses of Prolia. Osteoporosis is a condition that causes your bones to become thin and weak. * For more information about this side effect, see Side effect specifics below. For example, an over-the-counter pain reliever can often ease mild pain such as joint or muscle pain, or headache. Yoga for Osteoporosis: 5 Beneficial Poses, Diet and Osteoporosis: Nutrients, Diet Tips, and More. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Bone pain from Prolia may be most noticeable in your arms and legs. Some examples are atorvastatin (Lipitor) and rosuvastatin (Crestor). Costs of prescription drugs can vary depending on many factors. If you have questions about how to pay for your prescription, talk with your doctor or pharmacist. Mild side effects of Prolia that have been reported include: Mild side effects of many drugs may go away within a few days or a few weeks. You may have questions about Prolia and your treatment plan. You can also visit the Prolia manufacturers website to see if they have support options. Your FRAX score is your risk of having an osteoporosis-related fracture in the next 10 years. And ask your doctor about which drug is right for your condition. The drug may increase the risk of pregnancy loss. Tell your doctor if you become pregnant. What should I know about Prolia vs. Tymlos? Tell them if you have any scheduled dental work coming up. For more information, you can refer to the drugs prescribing information. Most Medicare plans and other insurance plans cover Prolia. (such as prednisone) for at least six months and are at high risk for fracture. You should not receive Prolia if you are allergic to denosumab, or if you Prolia is a RANKL inhibitor. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). Your doctor or pharmacist can tell you about any interactions these may cause with Prolia. More common side effects in females* who received Prolia for osteoporosis after menopause included: More common side effects in males* who received Prolia for osteoporosis included: More common side effects in people who received Prolia for osteoporosis due to drugs called glucocorticoids included: More common side effects in people who received Prolia to stop bone thinning due to certain cancer treatments included: For a complete list of all the side effects reported with Prolia, see the drugs prescribing information. Hair loss with Prolia was reported after the drugs initial studies were done and it was approved for use. (Biosimilars are like generic drugs. Hair loss wasnt reported as a side effect during clinical trials of Prolia. Prolia comes with a warning about a low level of calcium in the blood. You are encouraged to report negative side effects of prescription drugs to the FDA. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. With osteopenia, your bone mineral density (BMD) is lower than usual. See what this means for you in the chart below. Its recommended that you take 400 international units of vitamin D and 1,000 milligrams (mg) of calcium with Prolia. You should not receive Prolia if you are allergic to denosumab, or if you have: low levels of calcium in your blood (hypocalcemia); or. While youre receiving Prolia treatment, your doctor will monitor your cholesterol levels with regular blood tests. Taking medications, vaccines, foods, and other things with a certain drug can affect how the drug works. Its important to tell your doctor if you have serious or ongoing side effects. Before you start Prolia treatment, talk with your doctor about how long Prolias side effects may last. * For more information on this side effect, see the Side effect focus section below. It may also be higher if you have dental work done while youre taking Prolia. Prolia - Patient Information Leaflet (PIL) - (emc) - medicines What should be considered before taking Prolia? This information is intended only for U.S. healthcare professionals. Prolia Last updated on Feb 8, 2023. It is not known if the use of Prolia over a long period of time may cause slow healing of broken bones. in your skin, lower stomach area (abdomen), bladder, or ear may happen. Another common osteoporosis medication is denosumab (Prolia, Xgeva). They can also include swelling of your tongue, mouth, or throat, which can cause trouble breathing. If youd like to learn more about Prolia, talk with your doctor or pharmacist. This may help to protect healthy cells from damage. To see a side-by-side comparison of Prolia and Fosamax, view this drug article. Below, we answer some common questions about taking Prolia. Call your doctor right away if you have signs of infection such as: swelling, pain, tenderness, warmth, or redness anywhere on your body; pain and burning when you urinate, painful urination; bladder infection (painful or difficult urination); lung infection (cough, shortness of breath); cold symptoms such as stuffy nose, sneezing, sore throat; This is not a complete list of side effects and others may occur. These include osteonecrosis of the jawbone. But unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologic drugs.) Doctors sometimes prescribe Prolia to treat osteoporosis and bone thinning.
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